Clindamycin can also cause a more serious side effect called pseudomembranous colitis, which is an infection of the large intestine that can range in severity from mild to life-threatening. The solution, lotion, pledgets, and most brands of gel are applied twice a day. Apply topical clindamycin at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use topical clindamycin exactly as directed. Do not apply more or less of it or apply it more often than prescribed. I am suffering from basal pneumonia now I'm taking clindamycin 300mg twice a day is that ok to take twice a day only? Read More I have clindamycin 300 mg , can I safely double up todays med intake. Warning. Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including clindamycin hydrochloride and may range in severity from mild diarrhea to fatal colitis. While the foam and gel solutions are usually applied once a day, the lotion is usually applied twice a day and preferably at around the same time every day. The face should be cleaned with mild and non-medicated soap and pat dry before the application of clindamycin. He prescribed me differin, clindoxyl (Clindamycin and benzyl peroxide) and neo medrol two weeks ago. Since then i use differin every day, clindoyxl every other day and neo medrol i have only used twice. I have been put on Clindamycin HCL 150mg two a day twice a day for 10 days and I noticed on the bottle it says dont lay - Answered by a verified Doctor We use cookies to give you the best possible experience on our website. I have taken clindamycin HCL 300 mg twice a day for three days for strep. I am allergic to penicillin and have mild ulcerative proctitis. My gastroenterologist said ok to take this--not great--but ok. Take your doses spaced out evenly throughout the day, ideally every six hours. Swallow the capsules with a full glass of water. You can take clindamycin before or after food. Washing with a mild, bland soap 2 or 3 times a day should be enough, unless you have oily skin. If you have any questions about this, check with your doctor. If you have any questions about this, check with your doctor.